Enhanced Microscopic Definition of Campylobacter jejuni 81 - 176 Adherence to , Invasion 2 into , Translocation across , and Exocytosis from Polarized Human Intestinal Caco - 2 Cells
نویسندگان
چکیده
1 Laboratory of Enteric and Sexually Transmitted Diseases, FDA Center for Biologics Evaluation 8 and Research, 29 Lincoln Drive, NIH Campus, Bldg. 29/420, Bethesda, MD 20892; 2 FDA Center 9 for Food Safety and Applied Nutrition, College Park, Laurel MD 20708 10 11 12 Running Title: C. jejuni translocation across polarized Caco-2 cells 13
منابع مشابه
Enhanced microscopic definition of Campylobacter jejuni 81-176 adherence to, invasion of, translocation across, and exocytosis from polarized human intestinal Caco-2 cells.
Campylobacter jejuni-mediated pathogenesis involves gut adherence and translocation across intestinal cells. The current study was undertaken to examine the C. jejuni interaction with and translocation across differentiated Caco-2 cells to better understand Campylobacter's pathogenesis. The efficiency of C. jejuni 81-176 invasion of Caco-2 cells was two- to threefold less than the efficiency of...
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Campylobacter jejuni is a major foodborne pathogen that causes severe gastroenteritis in humans characterized by fever, diarrhea, and abdominal cramps. In the human gut, Campylobacter adheres and invades the intestinal epithelium followed by cytolethal distending toxin mediated cell death, and enteritis. Reducing the attachment and invasion of Campylobacter to intestinal epithelium and expressi...
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تاریخ انتشار 2008